ABSTRACT We recently showed that, in the absence of RecA-dependent homologous recombination, the Tnp26 transposase catalyzes cointegrate formation via a conservative reaction between two preexisting IS26, and this is strongly preferred over replicative transposition to a new site.Here, the reverse reaction was investigated by assaying for precise e
Summary: Human cytomegalovirus (HCMV) replicates its DNA genome in specialized replication compartments (RCs) in the host cell nucleus.These membrane-less organelles originate as spherical structures and grow in size over time.However, the mechanism of RC biogenesis has remained understudied.Using live-cell camif draps imaging and photo-oligomeriza
During the last decades the progresses of nanoscience and nanotechnology for biomedical application stimulated the transition from traditional drug delivery systems to the development of smart integrated nanosystems with stimuli-responsive characteristics.A wide range of smart integrated nanosystems have proven their effectiveness for various types
The moving target defense (MTD) is a proactive cybersecurity defense technique that constantly changes potentially vulnerable points to be attacked, to confuse the attackers, making it difficult for attackers to infer the system configuration and nullify reconnaissance activities to a victim system.We consider an MTD strategy for software-defined n